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Index > Protein center > NR5A2(Gene name) > Human
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  • NR5A2 (Gene name),
  • Nuclear receptor subfamily 5 group A member 2 (Protein name ),  NR5A2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NR5A2(B1F;CPF;FTF);
    Protein name:
    Nuclear receptor subfamily 5 group A member 2;
    Alternative:
    B1-binding factor(hB1F);Alpha-1-fetoprotein transcription factor;Hepatocytic transcription factor;CYP7A promoter-binding factor;Liver receptor homolog 1(LRH-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2.
    Function:
    Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    541
    Sequence:
    50:
    MSSNSDTGDL | QESLKHGLTP | IGAGLPDRHG | SPIPARGRLV | MLPKVETEAL | 
    100:
    GLARSHGEQG | QMPENMQVSQ | FKMVNYSYDE | DLEELCPVCG | DKVSGYHYGL | 
    150:
    LTCESCKGFF | KRTVQNNKRY | TCIENQNCQI | DKTQRKRCPY | CRFQKCLSVG | 
    200:
    MKLEAVRADR | MRGGRNKFGP | MYKRDRALKQ | QKKALIRANG | LKLEAMSQVI | 
    250:
    QAMPSDLTIS | SAIQNIHSAS | KGLPLNHAAL | PPTDYDRSPF | VTSPISMTMP | 
    300:
    PHGSLQGYQT | YGHFPSRAIK | SEYPDPYTSS | PESIMGYSYM | DSYQTSSPAS | 
    350:
    IPHLILELLK | CEPDEPQVQA | KIMAYLQQEQ | ANRSKHEKLS | TFGLMCKMAD | 
    400:
    QTLFSIVEWA | RSSIFFRELK | VDDQMKLLQN | CWSELLILDH | IYRQVVHGKE | 
    450:
    GSIFLVTGQQ | VDYSIIASQA | GATLNNLMSH | AQELVAKLRS | LQFDQREFVC | 
    500:
    LKFLVLFSLD | VKNLENFQLV | EGVQEQVNAA | LLDYTMCNYP | QQTEKFGQLL | 
    541:
    LRLPEIRAIS | MQAEEYLYYK | HLNGDVPYNN | LLIEMLHAKR | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    String:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    E0297h
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    MSDS:
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    96T
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    ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    E0297m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    E0297r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    E0297c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    U0297h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    U0297m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    U0297r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    U0297c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    P0297Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    P0297Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Cat.:
    P0297Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 5 group A member 2
    Protein for Human Nuclear receptor subfamily 5 group A member 2
    Protein for Human Nuclear receptor subfamily 5 group A member 2
    Protein for Human Nuclear receptor subfamily 5 group A member 2
    Protein for Human Nuclear receptor subfamily 5 group A member 2

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    References
    1. 1.
      "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus."
      Li M. , Xie Y.-H. , Kong Y.-Y. , Wu X. , Zhu L. , Wang Y.
      J. Biol. Chem.273:29022-29031(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING
      tissue: Liver.
    2. 2.
      Li M. , Xie Y.-H. , Wang Y.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Hepatoma.
    3. 3.
      "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene."
      Nitta M. , Ku S. , Brown C. , Okamoto A.Y. , Shan B.
      Proc. Natl. Acad. Sci. U.S.A.96:6660-6665(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Liver.
    4. 4.
      "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene."
      Zhang C.K. , Lin W. , Cai Y.N. , Xu P.L. , Dong H. , Li M. , Kong Y.Y. , Fu G. , Xie Y.H. , Huang G.M. , Wang Y.
      Gene273:239-249(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Trachea.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization."
      Galarneau L. , Drouin R. , Belanger L.
      Cytogenet. Cell Genet.82:269-270(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-541
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 300-541 IN COMPLEX WITH NCOA2 AND PHOSPHOLIPIDS
    11. 11.
      "Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity."
      Solomon I.H. , Hager J.M. , Safi R. , McDonnell D.P. , Redinbo M.R. , Ortlund E.A.
      J. Mol. Biol.354:1091-1102(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 79-187 IN COMPLEX WITH DNA;MUTAGENESIS OF TYR-96; PHE-168; 169-GLY-PRO-170 AND TYR-172
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 290-541 IN COMPLEX WITH NR0B2 AND PHOSPHOLIPID;MUTAGENESIS OF PHE-342 AND ILE-416
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 297-541 IN COMPLEX WITH NCOA2 AND PHOSPHOLIPID
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